Understanding how dormant ovarian cancer cells resist treatment
Evaluating unique aspects of quiescent ovarian cancer cell biology for therapeutic targets
['FUNDING_R01'] · MAGEE-WOMEN'S RES INST AND FOUNDATION · NIH-10883629
This study is looking at why some ovarian cancer cells can stay inactive and resist standard treatments, with the hope of finding new ways to help patients whose cancer comes back after treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAGEE-WOMEN'S RES INST AND FOUNDATION (nih funded) |
| Locations | 1 site (Pittsburgh, UNITED STATES) |
| Trial ID | NIH-10883629 on ClinicalTrials.gov |
What this research studies
This research investigates the unique biology of quiescent ovarian cancer cells, which are non-proliferating and often resistant to standard chemotherapy. By exploring the mechanisms behind this resistance, the study aims to identify new therapeutic targets that could improve treatment outcomes for patients with relapsed ovarian cancer. The researchers utilize advanced bioinformatics and molecular techniques to analyze the characteristics of these dormant cells and their role in driving chemotherapy resistance. The ultimate goal is to develop strategies that can effectively target these quiescent cells and enhance the efficacy of existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are ovarian cancer patients, particularly those who have experienced relapse after standard chemotherapy treatments.
Not a fit: Patients with early-stage ovarian cancer who have not yet undergone chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively target and eliminate chemotherapy-resistant ovarian cancer cells, improving survival rates for patients.
How similar studies have performed: Previous research has shown promise in targeting quiescent cancer cells, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Pittsburgh, UNITED STATES
- MAGEE-WOMEN'S RES INST AND FOUNDATION — Pittsburgh, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUCKANOVICH, RONALD J — MAGEE-WOMEN'S RES INST AND FOUNDATION
- Study coordinator: BUCKANOVICH, RONALD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.