Understanding how dormant malaria parasites form in the liver
Comparative transcriptomics of Plasmodium vivax strains to understand hypnozoite formation
['FUNDING_R21'] · UNIVERSITY OF GEORGIA · NIH-11110484
This study is looking into how the malaria parasite hides in the liver and what makes it go into a dormant state, which could help us find better ways to treat malaria and prevent it from coming back.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-11110484 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind the formation of dormant liver stages of the malaria parasite Plasmodium vivax, known as hypnozoites. By examining different strains of the parasite, the researchers aim to determine whether these dormant forms are predetermined before they invade liver cells. The study utilizes advanced techniques to analyze how these parasites behave in a controlled laboratory setting, which could lead to new treatments for malaria. The ultimate goal is to find ways to eliminate these dormant stages to reduce the burden of malaria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced malaria infections caused by Plasmodium vivax.
Not a fit: Patients with malaria caused by other strains of Plasmodium or those who have never been infected with malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate dormant malaria parasites, reducing the incidence of malaria infections.
How similar studies have performed: Previous research has shown some promise in understanding malaria parasite behavior, but this specific approach to studying hypnozoite formation is relatively novel.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOYNER, CHESTER J. — UNIVERSITY OF GEORGIA
- Study coordinator: JOYNER, CHESTER J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease