Understanding how dormant fungal spores become active
Official title: Investigation of uncharacterized fungal-specific genes in dormant conidia
Funded at University of Georgia · NIH-10765706 · Data updated 2026-11-12
This study is looking at the genes that help certain fungal spores, like Aspergillus fumigatus, stay inactive until the right conditions for growth come along, which could help us find new ways to treat fungal infections.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | January 18, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $75,500 |
| NIH project number | 5R03AI176262-02 |
| Project ID | NIH-10765706 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with compromised immune systems or those at risk for invasive fungal infections would be ideal candidates to benefit from this research.
✕Less likely to help
Patients with non-fungal infections or those not at risk for fungal diseases may not receive any benefit from this research.
What this research studies
This research investigates the genes responsible for the dormancy of fungal spores, specifically focusing on the human pathogen Aspergillus fumigatus. By analyzing genes that are highly active in dormant spores but less so in growing cells, the study aims to uncover the mechanisms that allow these spores to remain inactive until conditions are right for growth. The researchers will use techniques like gene deletion and tagging, flow cytometry, and microscopy to explore how these genes affect spore development and germination. This work could lead to new insights into fungal infections and potential antifungal targets.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antifungal treatments that target dormant spores, potentially reducing the incidence of invasive fungal infections.
How similar studies have gone: While the specific approach of targeting dormant fungal genes is relatively novel, similar research has shown promise in understanding fungal biology and developing antifungal strategies.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Momany, Michelle — University of Georgia
- Study coordinator: Momany, Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.