Understanding how dormant breast cancer cells can reactivate and cause metastasis
Epigenetic and metabolic bottlenecks of tumorigenesis
This study is looking at why some breast cancer cells can stay hidden and inactive for a long time after treatment but might come back later, and it aims to find new ways to stop these cells from causing cancer to return, which could help improve future treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10883160 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind dormant breast cancer cells that can remain inactive for long periods after treatment but may later reactivate and lead to metastasis. The team will explore how changes in chromatin, the material that makes up chromosomes, affect the behavior of these cells. By studying a specific histone variant and its role in cell fate transitions, the research aims to uncover new insights into how to prevent the recurrence of breast cancer. This could lead to improved therapies that target these dormant cells more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who have completed initial treatment and are at risk of recurrence due to dormant cancer cells.
Not a fit: Patients with early-stage breast cancer who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the recurrence of breast cancer by targeting dormant cancer cells.
How similar studies have performed: Previous research has shown promising results in understanding the role of chromatin remodeling in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Da Silva Gomes, Ana — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Da Silva Gomes, Ana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.