Understanding how dopamine signaling affects brain function and behavior
Structural Biology of Dopamine Signaling
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-10748373
This study is looking at how dopamine works in the brain to help us understand and improve treatments for conditions like schizophrenia and Huntington's disease, so we can create better medications for those who need them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10748373 on ClinicalTrials.gov |
What this research studies
This research investigates the dopamine signaling pathway, which plays a crucial role in regulating behaviors related to reward and is linked to various neurological disorders such as schizophrenia, Huntington's disease, and cognitive disorders. The study focuses on the structure and function of dopamine receptors, aiming to improve drug design for better therapeutic interventions. By utilizing advanced techniques like X-ray crystallography, the research seeks to uncover the mechanisms of dopamine receptors, which could lead to more effective treatments for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with schizophrenia, Huntington's disease, or other cognitive disorders related to dopamine dysfunction.
Not a fit: Patients with conditions unrelated to dopamine signaling or those who do not have cognitive disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective medications for neurological disorders associated with dopamine signaling.
How similar studies have performed: Previous research has shown promise in understanding dopamine receptors and their role in treatment, indicating that this approach has potential for success.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, WEI — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: LIU, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cognitive disease, cognitive disorder, cognitive syndrome, Cognition Disorders, Disorder