Understanding how dopamine circuits are affected by morphine use and withdrawal
Dopamine circuit regulation of morphine reinforcement across the opioid exposure cycle
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10983786
This study is looking at how long-term use of morphine affects the brain's reward system, especially in mice, to help us understand how opioid addiction develops and changes over time.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10983786 on ClinicalTrials.gov |
What this research studies
This research investigates how chronic exposure to morphine alters the dopamine system in the brain, particularly focusing on the ventral tegmental area (VTA). By studying both non-dependent and morphine-dependent mice, the researchers aim to identify how different types of dopamine neurons respond to morphine and the cues associated with its use. Advanced computational techniques will be employed to analyze the changes in these neurons during various stages of opioid exposure and withdrawal. The findings could provide insights into the neural mechanisms underlying opioid-use disorder and its progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of opioid use or those at risk of developing opioid dependence.
Not a fit: Patients who have never used opioids or those with non-opioid substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for opioid-use disorder.
How similar studies have performed: Previous research has shown promising results in understanding dopamine circuits related to substance use, indicating that this approach has potential for success.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JUAREZ, BARBARA — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: JUAREZ, BARBARA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.