Understanding how dopamine affects resilience to Alzheimer's disease
Dopaminergic mechanisms of resilience to Alzheimer's disease neuropathology
['FUNDING_R21'] · BRANDEIS UNIVERSITY · NIH-10809199
This study is looking at how differences in a brain chemical called dopamine might help some people keep their thinking skills even when they have early signs of Alzheimer's, and it's for anyone interested in understanding why some people cope better with this condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRANDEIS UNIVERSITY (nih funded) |
| Locations | 1 site (WALTHAM, UNITED STATES) |
| Trial ID | NIH-10809199 on ClinicalTrials.gov |
What this research studies
This research investigates how individual differences in the dopamine system may influence the effects of Alzheimer's disease-related brain changes on cognitive function. By examining a specific genetic variant associated with dopamine receptor activity, the study aims to uncover mechanisms that help some individuals maintain cognitive abilities despite the presence of Alzheimer's pathology. The research will utilize data from the Alzheimer's Disease Neuroimaging Initiative to analyze brain structure and function in cognitively normal individuals and those with mild cognitive impairment. This approach could lead to insights into neuroprotective factors that support cognitive resilience.
Who could benefit from this research
Good fit: Ideal candidates for this research are cognitively normal adults and those with mild cognitive impairment, particularly those with the DRD2 T/T genotype.
Not a fit: Patients with advanced Alzheimer's disease or those without the relevant genetic polymorphism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could identify genetic factors that help protect against cognitive decline in Alzheimer's disease, potentially leading to new therapeutic strategies.
How similar studies have performed: Previous research has shown that genetic factors related to dopamine receptors can influence cognitive resilience, suggesting a promising avenue for further exploration.
Where this research is happening
WALTHAM, UNITED STATES
- BRANDEIS UNIVERSITY — WALTHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERRY, ANNE SHIVELY — BRANDEIS UNIVERSITY
- Study coordinator: BERRY, ANNE SHIVELY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.