Understanding how dopamine affects behavior in the brain's basal ganglia
Towards a Unified Framework for Dopamine Signaling in the Striatum
This study looks at how certain brain cells that produce dopamine affect how we behave, helping us understand how our past experiences and feelings influence our choices, and it's designed for anyone interested in how our brains work when we make decisions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10687827 on NIH RePORTER |
What this research studies
This research investigates how dopamine-producing cells in the basal ganglia influence behavior in both animals and humans. By examining the interactions between these cells and the environment, the study aims to understand how past experiences and internal states shape future actions. A team of neurobiologists will use experimental and computational methods to develop unified theories that explain the role of dopamine in goal-oriented behavior. This research could provide insights into behavioral adaptations and decision-making processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological or psychiatric conditions that involve dopamine signaling.
Not a fit: Patients with conditions unrelated to dopamine signaling or those who do not have behavioral or neurological issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to dopamine dysfunction, such as Parkinson's disease and addiction.
How similar studies have performed: Previous research has shown success in understanding dopamine's role in behavior, making this approach both relevant and promising.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Sabatini, Bernardo L — Harvard Medical School
- Study coordinator: Sabatini, Bernardo L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.