Understanding how dopamine activity affects brain processes related to psychosis in mice
The role of spatiotemporal dopamine coordination in disrupted state representation processes in mice
This study is looking at how changes in brain chemicals called dopamine might affect thinking and learning in mice, which could help us understand more about psychosis and improve treatments for mental health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11109961 on NIH RePORTER |
What this research studies
This research investigates the relationship between dopamine activity in the brain and changes in how states are represented, particularly in the context of psychosis. Using mice as a model, the study focuses on how disruptions in dopamine signaling can affect cognitive control and reward learning. By employing advanced imaging techniques, researchers aim to explore the interactions between different brain regions and how these interactions contribute to the symptoms of psychosis. The findings could provide insights into the underlying mechanisms of mental health disorders and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals experiencing psychosis or related cognitive disorders.
Not a fit: Patients with conditions unrelated to dopamine dysregulation or those not experiencing cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of psychosis and potentially new therapeutic approaches for managing related cognitive impairments.
How similar studies have performed: While this research explores novel aspects of dopamine dynamics, similar studies have shown promise in understanding the role of dopamine in cognitive processes and mental health disorders.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Hamid, Arif a — University of Minnesota
- Study coordinator: Hamid, Arif a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.