Understanding how donor immune cells affect complications in cancer treatment
DOT1L, reconstitution of plasmacytoid dendritic cells and alloimmunity
This study is looking at how a type of immune cell called plasmacytoid dendritic cells (pDCs) can help prevent graft-versus-host disease (GVHD) in cancer patients who have had stem cell transplants, and it aims to find ways to improve these cells to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-10818559 on NIH RePORTER |
What this research studies
This research investigates graft-versus-host disease (GVHD), a serious complication that can occur in cancer patients after receiving stem cell transplants. It focuses on the role of plasmacytoid dendritic cells (pDCs), which are crucial for immune protection, and how their failure to reconstitute can worsen GVHD. The study uses both animal models and human samples to explore the molecular defects in pDCs caused by GVHD and how restoring these cells can improve patient outcomes. By examining the interactions between donor immune cells and the recipient's immune system, the research aims to identify potential therapeutic strategies to mitigate GVHD.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are undergoing allogeneic hematopoietic cell transplantation and are at risk for developing GVHD.
Not a fit: Patients who are not undergoing stem cell transplants or those who do not have a risk of GVHD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancer patients undergoing stem cell transplants, reducing the incidence and severity of GVHD.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in GVHD, indicating that this approach has potential for success.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Zhang, Yi — Hackensack University Medical Center
- Study coordinator: Zhang, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.