Understanding how DND1 influences male germ cell development during cell cycle arrest
DND1 Mediates Epigenetic Reprogramming During Cell Cycle Arrest In Male Germ Cells
This study is looking at how a protein called DND1 affects the development of male reproductive cells, which could help us understand more about fertility and how these cells change during a key stage of their growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10862860 on NIH RePORTER |
What this research studies
This research investigates the role of the DND1 protein in the epigenetic reprogramming of male germ cells during a critical phase of cell cycle arrest. By using advanced techniques like ATAC sequencing, the study aims to determine how different populations of male germ cells are affected by changes in chromatin structure and gene expression. The researchers will explore whether all male germ cells undergo similar reprogramming or if specific sub-populations are targeted, which could have implications for fertility and germ cell development. This work is conducted using a transgenic mouse model that allows for the observation of DND1's effects in real-time.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include young males experiencing fertility issues or those with conditions affecting germ cell development.
Not a fit: Patients who are not male or those over the age of 21 may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into male fertility and the development of therapies for infertility related to germ cell dysfunction.
How similar studies have performed: While the specific approach of studying DND1 in this context may be novel, similar research has shown success in understanding epigenetic regulation in other cell types.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Capel, Blanche — Duke University
- Study coordinator: Capel, Blanche
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.