Understanding how DNA's hidden parts and 3D shape control our genes
High throughput interrogation of non-coding variants and 3D genome organization
This project looks at how the parts of our DNA that don't make proteins, along with the way DNA folds up in 3D, influence how our genes work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11141058 on NIH RePORTER |
What this research studies
This project aims to uncover how specific sections of our DNA, which don't directly code for proteins, actually influence gene activity. Researchers are also exploring how the intricate 3D folding of our DNA within cells helps distant regulatory elements communicate with their target genes. By using advanced tools like CRISPR gene editing and methods that map DNA's 3D structure, we hope to identify which of these non-coding regions are truly important. This work will help us understand the complex rules that govern how our genes are turned on and off.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this knowledge could benefit individuals with genetic conditions or diseases linked to gene regulation.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide a fundamental understanding of gene regulation, which is crucial for understanding the origins of many diseases and developing new therapies.
How similar studies have performed: While the specific high-throughput methods are advanced, the general approach of studying gene regulation and 3D genome organization is an active and promising area of research with ongoing successes.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Yue, Feng — Northwestern University
- Study coordinator: Yue, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.