Understanding how DNAPKcs helps repair DNA breaks and resist damage from cancer treatments
Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistance
This study is looking at a protein called DNAPKcs that helps fix DNA damage in cancer cells, and it's testing new ways to block this protein so that tumors become more responsive to treatments like radiation, which could lead to better outcomes for patients based on their specific tumor characteristics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11043511 on NIH RePORTER |
What this research studies
This research investigates the role of DNAPKcs, a protein involved in repairing DNA breaks, particularly in the context of cancer treatment. By developing inhibitors that target DNAPKcs, the study aims to make tumors more sensitive to treatments that cause chromosomal damage, such as radiotherapy. The research will explore how DNAPKcs interacts with other proteins to repair DNA and how this knowledge can help predict which tumors will respond best to these treatments. Patients may benefit from improved treatment strategies based on their tumor's genetic background.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that exhibit resistance to radiation or other clastogenic therapies.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not involve chromosomal breaks may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by identifying which patients will benefit most from specific therapies.
How similar studies have performed: Other research has shown promise in targeting DNA repair mechanisms to enhance the effectiveness of cancer treatments, indicating a potential for success in this area.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Stark, Jeremy Michael — Beckman Research Institute/city of Hope
- Study coordinator: Stark, Jeremy Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.