Understanding how DNA viruses produce and respond to double-stranded RNA
dsRNA production and sensing during DNA virus infection
['FUNDING_OTHER'] · WISTAR INSTITUTE · NIH-10918290
This study looks at how our cells respond to a specific type of genetic material made during infections from certain viruses, like adenoviruses, to better understand how our immune system fights off these infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10918290 on ClinicalTrials.gov |
What this research studies
This research investigates the production of double-stranded RNA (dsRNA) during infections caused by DNA viruses, particularly adenoviruses. It explores how cells detect this dsRNA to trigger anti-viral responses, challenging previous assumptions about dsRNA presence in these infections. The study employs advanced techniques such as RNA sequencing and quantitative mass spectrometry to analyze the immune response to dsRNA produced by viral mutants. By examining these interactions, the research aims to uncover new insights into viral behavior and host defenses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with adenoviruses or other DNA viruses.
Not a fit: Patients with infections caused by RNA viruses or those without viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for detecting and treating infections caused by DNA viruses.
How similar studies have performed: While the approach of studying dsRNA in DNA virus infections is relatively novel, similar research has shown promise in understanding viral-host interactions.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRICE, ALEXANDER MATTHEW — WISTAR INSTITUTE
- Study coordinator: PRICE, ALEXANDER MATTHEW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adenoviridae Infections, Adenovirus Infections