Understanding how DNA synthesis is completed
Mechanisms that ensure the completion of DNA synthesis
This study is looking at how our cells make sure DNA is copied correctly, especially after it gets damaged, and it’s for anyone interested in understanding why mistakes in DNA copying can lead to problems like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10897004 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that ensure DNA synthesis is completed accurately, which is crucial for maintaining genetic stability. It focuses on how DNA replication can be restarted after damage and how certain proteins, like topoisomerases, help manage the process of DNA replication. By studying these mechanisms, the research aims to uncover why some DNA replication processes fail and how they can be improved. This could lead to better understanding of conditions like cancer, where DNA replication errors are common.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast or ovarian cancer, particularly those with mutations in the BRCA1 or BRCA2 genes.
Not a fit: Patients without genetic predispositions to breast or ovarian cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers associated with DNA replication errors, potentially enhancing patient outcomes.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms, making this approach promising for further advancements.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Dewar, James M — Vanderbilt University
- Study coordinator: Dewar, James M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.