Understanding how DNA structures affect genome stability
Replication through DNA Structures and Consequences for Genome Stability
['FUNDING_OTHER'] · TUFTS UNIVERSITY MEDFORD · NIH-11000817
This study is looking at how certain repeated DNA sequences, like those linked to Huntington's disease, can mess up the way our cells copy and fix DNA, and by understanding this, we hope to learn more about preventing genetic diseases and cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY MEDFORD (nih funded) |
| Locations | 1 site (Boston, UNITED STATES) |
| Trial ID | NIH-11000817 on ClinicalTrials.gov |
What this research studies
This research investigates how repetitive DNA sequences can form structures that disrupt normal DNA replication and repair processes. By studying these structures, particularly CAG repeats associated with diseases like Huntington's, the research aims to uncover the cellular mechanisms that prevent harmful mutations and chromosome breakage. The approach involves examining how proteins are modified and interact with nuclear components during DNA replication. This knowledge could lead to better understanding of genetic diseases and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions associated with CAG repeat expansions, such as Huntington's disease or myotonic dystrophy.
Not a fit: Patients without genetic conditions related to DNA instability or those not affected by CAG repeat expansions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating genetic diseases and cancers linked to DNA instability.
How similar studies have performed: Other research has shown success in understanding DNA replication issues related to repetitive sequences, making this approach both relevant and promising.
Where this research is happening
Boston, UNITED STATES
- TUFTS UNIVERSITY MEDFORD — Boston, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREUDENREICH, CATHERINE H — TUFTS UNIVERSITY MEDFORD
- Study coordinator: FREUDENREICH, CATHERINE H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell, cancer initiation