Understanding how DNA structure determines centromere location
Official title: Investigating the role of DNA structure in centromere specification
Funded at Emory University · NIH-11015782 · Data updated 2026-11-12
This study is looking at how the structure of DNA helps determine where centromeres are located on chromosomes, which is important for making sure cells divide correctly, and it uses samples from patients to understand how problems with centromeres can lead to diseases like cancer, with the hope of finding new ways to treat these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31GM153153-02 |
| Project ID | NIH-11015782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chromosomal disorders or cancers linked to aneuploidy.
✕Less likely to help
Patients without chromosomal abnormalities or related conditions may not benefit from this research.
What this research studies
This research investigates the role of DNA structure in defining the position of centromeres, which are crucial for proper chromosome segregation during cell division. By examining the unique nucleosomes and DNA sequences that characterize centromeres, the study aims to uncover how these elements contribute to the stability and functionality of centromeres. The research utilizes patient-derived samples to explore the formation of ectopic centromeres, which can lead to chromosomal abnormalities and diseases such as cancer. Through this approach, the study seeks to identify potential mechanisms that could be targeted for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions associated with chromosomal abnormalities, including certain cancers.
How similar studies have gone: While the investigation of centromere biology is ongoing, this specific approach to understanding neocentromeres is relatively novel and has not been extensively tested.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Gutema, Lydia Habtamu — Emory University
- Study coordinator: Gutema, Lydia Habtamu
Related research
Other NIH-funded projects on the same topics.
-
Administrative and Engagement Core for Breast Cancer Breakthrough in Kenya
A national effort in Kenya to speed up how we screen for breast cancer and connect women to treatment, using teamwork across institutions.
-
Collaborative research program to advance patient care
A multi-project research effort at Emory University aims to push forward medical knowledge that could help people with illnesses in the future.
-
Project-003: A multi-partner research program at Emory University
A multi-faceted NIH grant at Emory University aims to advance understanding in a focused area over several years to benefit patients with diseases or conditions connected to the research.
-
Project-002: advancing patient care through coordinated research at Emory
A multi-project NIH grant at Emory aims to translate findings into better care for people with a health condition by coordinating research efforts across teams.
-
Project-006: A Multidisciplinary Emory Initiative to Advance Medical Understanding
A multi-project NIH grant at Emory University aims to push forward medical knowledge in areas that could eventually help patients.
-
Project-005: A multi-component research effort at Emory University
A multi-part NIH grant from Emory University aims to advance understanding in a specific health area over several years with potential patient benefits in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.