Understanding how DNA structure determines centromere location
Investigating the role of DNA structure in centromere specification
This study is looking at how the structure of DNA helps determine where centromeres are located on chromosomes, which is important for making sure cells divide correctly, and it uses samples from patients to understand how problems with centromeres can lead to diseases like cancer, with the hope of finding new ways to treat these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11015782 on NIH RePORTER |
What this research studies
This research investigates the role of DNA structure in defining the position of centromeres, which are crucial for proper chromosome segregation during cell division. By examining the unique nucleosomes and DNA sequences that characterize centromeres, the study aims to uncover how these elements contribute to the stability and functionality of centromeres. The research utilizes patient-derived samples to explore the formation of ectopic centromeres, which can lead to chromosomal abnormalities and diseases such as cancer. Through this approach, the study seeks to identify potential mechanisms that could be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chromosomal disorders or cancers linked to aneuploidy.
Not a fit: Patients without chromosomal abnormalities or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions associated with chromosomal abnormalities, including certain cancers.
How similar studies have performed: While the investigation of centromere biology is ongoing, this specific approach to understanding neocentromeres is relatively novel and has not been extensively tested.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Gutema, Lydia Habtamu — Emory University
- Study coordinator: Gutema, Lydia Habtamu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.