Understanding how DNA structure affects gene regulation
Harnessing the chromatin conformational code for epigenetic regulation
This study is looking at how the structure of DNA and proteins in our cells can change and affect how genes work, with the goal of creating new tools that could help us understand these changes better and find new ways to treat cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10473051 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin, the complex of DNA and proteins in the cell nucleus, in regulating gene expression. By exploring how the structure of nucleosomes, which are the building blocks of chromatin, can change and influence cellular functions, the research aims to develop new tools to study these dynamics. The approach involves creating specialized sensors that can detect different shapes of nucleosomes, providing insights into how these changes affect gene activity and potentially lead to new cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer, particularly those whose conditions may be influenced by epigenetic factors.
Not a fit: Patients with non-malignant conditions or those not affected by epigenetic regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for cancers by targeting the mechanisms that regulate gene expression.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics and its implications for cancer treatment, suggesting that this approach could be a significant advancement in the field.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Sanulli, Serena — Stanford University
- Study coordinator: Sanulli, Serena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.