Understanding how DNA shape affects CRISPR's ability to target genes
Elucidating the Role of DNA Shape in CRISPR Target Discrimination
This study is looking at how the shape of DNA affects the way CRISPR tools, like Cas9 and Cas12a, find and edit specific genes, with the goal of making gene editing safer and more precise for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11017816 on NIH RePORTER |
What this research studies
This research investigates the physical properties of DNA, specifically its shape, and how these properties influence the ability of CRISPR systems, like Cas9 and Cas12a, to accurately target specific genes. By focusing on the mechanisms of target discrimination, the study aims to enhance the precision of CRISPR technology, which is crucial for its safe application in gene editing. The researchers will explore how DNA shape interacts with RNA guides and target DNA sequences to improve the specificity of CRISPR, potentially reducing unwanted effects during gene editing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions that could benefit from precise gene editing techniques.
Not a fit: Patients with conditions that do not involve genetic mutations or those who are not candidates for gene editing therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective gene editing therapies for various genetic disorders.
How similar studies have performed: Previous research has shown promising results in improving CRISPR specificity through various approaches, indicating that this line of investigation has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Qin, Peter Z — University of Southern California
- Study coordinator: Qin, Peter Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.