Understanding how DNA sequences regulate gene expression using advanced computer models
Reliable post hoc interpretations of deep learning in genomics
['FUNDING_R01'] · COLD SPRING HARBOR LABORATORY · NIH-11074078
This study is exploring how certain proteins interact with parts of our DNA that don't code for genes to help control how genes are turned on or off, and the findings could lead to better, more personalized treatments for patients with different health conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLD SPRING HARBOR LABORATORY (nih funded) |
| Locations | 1 site (COLD SPRING HARBOR, UNITED STATES) |
| Trial ID | NIH-11074078 on ClinicalTrials.gov |
What this research studies
This research investigates how transcription factors interact with non-coding DNA to regulate gene expression, utilizing advanced deep learning techniques. By developing methods to interpret the predictions made by deep neural networks, the project aims to uncover important features of DNA sequences that influence gene regulation. Patients may benefit from insights gained about genetic factors that contribute to various conditions, potentially leading to more personalized treatment approaches. The research will involve analyzing genomic data to improve the understanding of regulatory mechanisms at a detailed level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or those interested in understanding the genetic basis of their health issues.
Not a fit: Patients without genetic conditions or those not interested in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic regulation, enabling more personalized and effective treatments for patients with genetic disorders.
How similar studies have performed: Other research has shown promise in using deep learning for genomic analysis, but the specific interpretability methods proposed in this project are novel.
Where this research is happening
COLD SPRING HARBOR, UNITED STATES
- COLD SPRING HARBOR LABORATORY — COLD SPRING HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOO, PETER K — COLD SPRING HARBOR LABORATORY
- Study coordinator: KOO, PETER K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.