Understanding how DNA sequences interact with proteins in cells
Official title: Uncovering the role of a new DNA sequence pattern in nucleosome-protein interactions
Funded at Rochester Institute of Technology · NIH-11006573 · Data updated 2026-11-12
This study is looking at how certain patterns in DNA can affect the way proteins called transcription factors attach to DNA, which is important for controlling how genes work in our cells.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rochester Institute of Technology NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $46,630 |
| NIH project number | 3R15GM149587-01S1 |
| Project ID | NIH-11006573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions that may be influenced by transcription factor activity and nucleosome interactions.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or those not affected by transcription factor interactions may not benefit from this research.
What this research studies
This research investigates the interactions between DNA sequences and proteins called transcription factors within nucleosomes, which are structures that package DNA in cells. The study focuses on a specific pattern of DNA sequences that may influence how these proteins bind to DNA. By examining the structural features of nucleosomal DNA and its interactions with histones, the research aims to uncover new insights into gene regulation. The methodology includes analyzing the periodic patterns of DNA sequences and their effects on protein binding, which could enhance our understanding of cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, potentially benefiting patients with genetic disorders.
How similar studies have gone: While the specific approach of this research is novel, previous studies have successfully explored DNA-protein interactions, indicating potential for meaningful findings.
Where this research is happening
-
Rochester Institute of Technology
Rochester, United States Active
Researchers
- Principal investigator: Cui, Feng — Rochester Institute of Technology
- Study coordinator: Cui, Feng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.