Understanding how DNA sequences control genetic recombination during cell division
Systematic elucidation of DNA sequence codes that regulate meiotic recombination
This study looks at how certain DNA patterns help control a process called meiotic recombination, which is important for creating genetic diversity and ensuring chromosomes separate correctly during cell division, using fission yeast to learn more about how this works and what it might mean for understanding genetic disorders and fertility problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-11055982 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which specific DNA sequences influence meiotic recombination, a crucial process for genetic diversity and proper chromosome segregation. Using fission yeast as a model organism, the study explores how certain DNA motifs and their associated proteins regulate the initiation of recombination at designated hotspots in the genome. By analyzing thousands of DNA sequences, the researchers aim to identify key elements that activate these recombination hotspots, which could have implications for understanding genetic disorders and fertility issues. The findings may provide insights into the fundamental processes of genetics and evolution.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders related to meiotic recombination, such as chromosome 21 trisomy syndrome.
Not a fit: Patients with conditions unrelated to genetic recombination or those not affected by chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic recombination, potentially leading to improved treatments for genetic disorders and fertility issues.
How similar studies have performed: Previous research has shown success in understanding genetic recombination mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
Little Rock, United States
- Univ of Arkansas for Med Scis — Little Rock, United States (Active)
Researchers
- Principal investigator: Wahls, Wayne P — Univ of Arkansas for Med Scis
- Study coordinator: Wahls, Wayne P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.