Understanding how DNA replication timing affects genetic diseases and cancer
Official title: The Genetic Basis of Human DNA Replication Timing
Funded at Roswell Park Cancer Institute Corp · NIH-11002006 · Data updated 2026-11-12
This study is looking at how and when our DNA copies itself in order to better understand how problems with this process might lead to genetic diseases and cancer, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $412,236 |
| NIH project number | 5R35GM148071-03 |
| Project ID | NIH-11002006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic disorders or a family history of cancer.
✕Less likely to help
Patients with no genetic predisposition to diseases related to DNA replication timing may not receive benefit from this research.
What this research studies
This research investigates the timing of DNA replication across the human genome and its implications for genetic diseases and cancer. By developing innovative experimental and computational methods, the team aims to create the largest dataset of human DNA replication timing to date. They will explore how this timing interacts with gene expression and the epigenome, potentially revealing critical insights into the mechanisms that govern these processes. Patients may benefit from a deeper understanding of how abnormal DNA replication can lead to genetic disorders and cancer.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic basis of diseases and inform future therapeutic strategies.
How similar studies have gone: Previous research has shown promising results in linking DNA replication timing to genetic variation, indicating that this approach has potential for significant discoveries.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Koren, Amnon — Roswell Park Cancer Institute Corp
- Study coordinator: Koren, Amnon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.