Understanding how DNA replication starts in cells
Mechanisms for recruitment and function of metazoan replication initiation factors
This study is looking at how cells start copying their DNA and how certain changes in the DNA can lead to diseases like cancer, so we can better understand these processes and help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11052575 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells initiate DNA replication, focusing on the role of specific proteins that bind to DNA and help load the necessary machinery for replication. By studying these processes in metazoan systems, the research aims to uncover how certain mutations associated with diseases can affect DNA replication. The approach combines biochemical experiments, structural analysis, and cell-based methods to provide a comprehensive understanding of these initiation factors. Patients may benefit from insights gained into how disruptions in DNA replication can lead to various diseases, including cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations that affect DNA replication or those with conditions like Basal Cell Nevus Syndrome.
Not a fit: Patients with conditions unrelated to DNA replication or those not carrying relevant genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for diseases linked to DNA replication errors, including certain cancers.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms in simpler organisms, but this specific focus on metazoan systems is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Bleichert, Franziska — Yale University
- Study coordinator: Bleichert, Franziska
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.