Understanding how DNA replication is started and regulated in cells.
Studies to Explore DNA Replication Proteins in Functional Assemblies through Intrinsically Disordered Domains
This study looks at how certain proteins help start and control the process of DNA copying in our cells, which is important for understanding cell division and could lead to better treatments for cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10768664 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that initiate and regulate DNA replication in cells. It focuses on specific proteins and their interactions, particularly how certain regions of these proteins, which are intrinsically disordered, help in binding DNA and forming functional assemblies. By exploring these interactions, the research aims to uncover how DNA replication is coordinated and how it affects cell function. Patients may benefit from insights gained into the fundamental processes of cell division and replication, which are crucial in cancer biology.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with cancers or genetic disorders related to DNA replication.
Not a fit: Patients with conditions unrelated to DNA replication or cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer cell replication, potentially improving treatment outcomes.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms, making this approach promising but still exploring novel aspects.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Botchan, Michael R. — University of California Berkeley
- Study coordinator: Botchan, Michael R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.