Understanding how DNA replication is controlled to maintain genome stability
Developmental control of replication initiation and genome stability
This study looks at how cells make copies of their DNA when they divide, using fruit flies to find out which proteins help this process, so we can better understand how our genetic information stays stable as we grow.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11001497 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate DNA replication during cell division, which is crucial for maintaining genome stability. By using the developmental model organism Drosophila, the research aims to identify key regulators involved in the DNA replication process. The study focuses on understanding the relationship between nuclear pore proteins and the Origin Recognition Complex, as well as the molecular mechanisms that influence replication initiation. Insights gained from this research could help clarify how genome stability is preserved during development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who may be affected by conditions related to genome stability and DNA replication.
Not a fit: Patients who are over 21 years old or do not have conditions related to genome instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing genome instability, which is a key factor in cancer development.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms, but this specific approach using Drosophila is relatively novel.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Nordman, Jared — Vanderbilt University
- Study coordinator: Nordman, Jared
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.