Understanding how DNA replication is controlled in mammalian cells
Regulation of re-replication in mammalian cells
This study looks at how certain proteins help control DNA copying in our cells, especially focusing on a protein called SET8, to understand how problems in this process can lead to cancer, which could help us find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10757392 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate DNA replication in mammalian cells, focusing on how certain proteins influence the initiation of replication during the cell cycle. The study aims to uncover the role of the histone methyltransferase SET8 and its impact on genomic stability, which is crucial for preventing cancer. By examining how disruptions in these mechanisms can lead to genomic instability, the research seeks to provide insights into the underlying causes of malignant transformations. Patients may benefit from a better understanding of cancer development and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with malignancies that may be linked to genomic instability.
Not a fit: Patients with non-cancerous conditions or those not affected by genomic instability may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by targeting the mechanisms of DNA replication.
How similar studies have performed: Other research has shown promising results in understanding DNA replication mechanisms, suggesting that this approach could yield valuable insights into cancer biology.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Abbas, Tarek a. — University of Virginia
- Study coordinator: Abbas, Tarek a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.