Understanding how DNA replication is controlled during animal development
Epigenetic Control of the Cell Cycle During Animal Development
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11036830
This study looks at how our cells copy their DNA, which is really important for healthy growth and development, especially in understanding cancer, and it aims to find out how certain proteins help keep this process running smoothly so that we can learn more about what goes wrong in diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11036830 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that regulate DNA replication during the cell cycle, which is crucial for normal animal development and health. It focuses on how chromatin assembly and organization affect genome replication, particularly in the context of cancer. By studying the synthesis of histone proteins and their role in packaging DNA, the research aims to uncover the fundamental processes that ensure accurate genome replication. Patients may benefit from insights gained into how disruptions in these processes can lead to diseases, especially cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with conditions related to cell cycle dysregulation.
Not a fit: Patients with conditions unrelated to DNA replication or cell cycle control may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by targeting the mechanisms of DNA replication.
How similar studies have performed: Previous research has shown that understanding chromatin dynamics and DNA replication can lead to significant advancements in cancer treatment, indicating a promising avenue for this investigation.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DURONIO, ROBERT J — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: DURONIO, ROBERT J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers