Understanding how DNA replication and transcription work together during development
Official title: Illuminating the Molecular Mechanisms of Replication and Transcription Coordination
Funded at University of Pennsylvania · NIH-11070232 · Data updated 2026-11-12
This study looks at how DNA copying and reading work together in tiny fruit fly embryos, using special cameras to see these processes in action, which helps us understand important steps in development better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM157882-01 |
| Project ID | NIH-11070232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a keen interest in the molecular biology of development, particularly those affected by cancers or degenerative neurological disorders.
✕Less likely to help
Patients who are not affected by developmental disorders or cancers may not receive direct benefits from this research.
What this research studies
This research investigates the coordination of DNA replication and transcription at the molecular level during embryonic development. By using advanced live microscopy and single molecule tracking in Drosophila embryos, the study aims to observe how transcription machinery interacts with replication proteins in real time. This approach challenges previous assumptions about the complete eviction of transcription factors during DNA replication, providing new insights into cellular processes that are crucial for development.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the molecular mechanisms involved in developmental processes and potentially inform treatments for cancers and degenerative diseases.
How similar studies have gone: While this research explores novel approaches to understanding transcription and replication coordination, similar studies have shown promising results in elucidating molecular interactions in other contexts.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Adigun, Alexandria — University of Pennsylvania
- Study coordinator: Adigun, Alexandria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.