Understanding how DNA replication and transcription interact
Mapping transient interactions with and on genomic DNA
This study is looking at how DNA copying and reading can sometimes get in each other's way, which might cause problems in our genes, and it's especially focused on understanding how this affects diseases like cancer, so that we can find better ways to help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11011754 on NIH RePORTER |
What this research studies
This research investigates the conflicts that occur between DNA replication and transcription processes in cells, which can lead to genome instability. By developing new tools, the project aims to identify where these conflicts happen in the genome and how they affect DNA function. The study focuses on the role of helicases, enzymes that unwind DNA, and their involvement in various diseases, including cancer. Patients may benefit from insights gained about how these processes contribute to disease progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting DNA repair mechanisms or those at risk for cancer due to genomic instability.
Not a fit: Patients with conditions unrelated to DNA replication or transcription processes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for diseases related to DNA damage, including cancer.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, but this specific approach to mapping helicase activity is relatively novel.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Smith, Duncan J — New York University
- Study coordinator: Smith, Duncan J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.