Understanding how DNA replication and repair work
Structural basis of replisome mediated DNA replication and repair
This study is looking at how a special team of proteins helps our DNA copy itself and fix any mistakes, which is really important for keeping our genes healthy, and it’s designed for anyone interested in understanding how our bodies protect their DNA from damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11088867 on NIH RePORTER |
What this research studies
This research investigates the complex processes involved in DNA replication and repair, focusing on a multi-protein complex known as the replisome. By using advanced techniques like cryo-electron microscopy, the team aims to uncover how the replisome operates under normal and stressful conditions, which is crucial for maintaining genetic stability. The study will utilize a model system from bacteriophage T7 to explore how the replisome responds to replication barriers and triggers DNA repair mechanisms. This research could provide insights into the fundamental processes that protect our DNA from damage and contribute to human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers linked to DNA replication and repair issues.
Not a fit: Patients with conditions unrelated to DNA replication or repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases related to DNA damage, including various cancers.
How similar studies have performed: Previous research has shown success in understanding DNA replication mechanisms, but this specific approach using cryo-EM is relatively novel.
Where this research is happening
Houston, United States
- Rice University — Houston, United States (Active)
Researchers
- Principal investigator: Gao, Yang — Rice University
- Study coordinator: Gao, Yang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.