Understanding how DNA replication and cell division work.
Official title: DNA Replication and Cytokinesis.
Funded at University of Alabama at Birmingham · NIH-11093778 · Data updated 2026-11-12
This study is looking at how certain proteins help with DNA copying and cell division, using fruit flies and human cells to learn more about their important roles in keeping our cells healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $39,311 |
| NIH project number | 3R35GM148158-02S1 |
| Project ID | NIH-11093778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cell division and DNA replication, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to DNA replication or cell division may not benefit from this research.
What this research studies
This research investigates the roles of specific proteins, Orc6 and ORC, in the processes of DNA replication and cell division (cytokinesis) using fruit flies and human cells as models. The study aims to uncover how these proteins function at a molecular level, particularly focusing on their interactions with other cellular components. By purifying and analyzing these proteins, researchers hope to gain insights into their essential roles in cell division and DNA synthesis, which are critical for healthy cell function.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cell division and DNA replication, potentially informing treatments for diseases related to these processes.
How similar studies have gone: Previous research has shown success in understanding similar protein functions in cell division and DNA replication, indicating that this approach is grounded in established scientific principles.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Chesnokov, Igor N — University of Alabama at Birmingham
- Study coordinator: Chesnokov, Igor N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.