Understanding how DNA repairs itself to prevent cancer
Regulation of DNA Excision Repair in Chromatin
This study is looking at how our cells fix damaged DNA, especially after exposure to UV light, and it aims to help people with certain genetic conditions that make it harder for their bodies to repair DNA, so they can better understand their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project ID | NIH-11125842 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which DNA repairs itself after damage, particularly focusing on how chromatin structure affects the efficiency of DNA repair processes. The study utilizes a novel high-throughput sequencing method called MNase-CPD-seq to analyze how damaged DNA is recognized and repaired in cells exposed to UV radiation. By examining the dynamics of nucleosomes and their positioning during repair, the research aims to uncover critical factors that influence DNA repair pathways, which are essential for maintaining genome stability and preventing cancer. Patients with specific genetic predispositions to DNA repair deficiencies may benefit from the insights gained from this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic conditions that affect DNA repair, such as Xeroderma pigmentosum or other cancer predisposition syndromes.
Not a fit: Patients without any known genetic predispositions to DNA repair deficiencies or those not affected by cancer-related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA repair mechanisms, potentially informing new treatments for cancer and genetic disorders related to DNA repair deficiencies.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, but this specific approach using MNase-CPD-seq is relatively novel and aims to provide new insights.
Where this research is happening
Pullman, United States
- Washington State University — Pullman, United States (Active)
Researchers
- Principal investigator: Wyrick, John J — Washington State University
- Study coordinator: Wyrick, John J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.