Understanding how DNA repairs itself to prevent cancer
Mechanisms of DNA damage processing and the initiation of Nucleotide Excision Repair
This study is looking at how our bodies fix damaged DNA, which is important for preventing diseases like cancer, and it hopes to find new ways to improve treatments for patients by understanding this repair process better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor University NIH-funded |
| Lab location | 1 site (Waco, United States) |
| Project ID | NIH-10513526 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind nucleotide excision repair (NER), a crucial process that helps fix various types of DNA damage. By using advanced techniques like cryo-electron microscopy and mass spectrometry, the study aims to uncover the structural details of how NER is initiated. This understanding could lead to new insights into how genetic defects in this repair system contribute to cancer and other diseases. Patients may benefit from improved therapies targeting these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to cancer or those affected by conditions related to DNA repair deficiencies.
Not a fit: Patients with cancers unrelated to DNA repair mechanisms may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by targeting the DNA repair processes that are often faulty in cancer cells.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
Waco, United States
- Baylor University — Waco, United States (Active)
Researchers
- Principal investigator: Min, Jung-Hyun — Baylor University
- Study coordinator: Min, Jung-Hyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.