Understanding how DNA repairs itself and maintains chromosome structure
Single-molecule Visualization and Mechanisms of DNA Recombination and Intersecting DNA Transactions
This study is looking at how our cells fix DNA damage, which is really important for keeping us healthy, and by understanding this process better, we hope to find new ways to help people with genetic disorders and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11062438 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of homologous recombination, a critical process for DNA repair and chromosome maintenance in both bacteria and eukaryotic cells. By using advanced techniques to visualize single molecules, researchers will analyze how proteins interact with DNA during repair processes. The study involves recreating complex biological reactions in the lab to better understand the steps involved in DNA repair and replication. Patients may benefit from insights gained into how DNA damage is repaired, which could inform treatments for genetic disorders and cancers.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or cancers related to DNA repair mechanisms.
Not a fit: Patients with conditions unrelated to DNA repair or chromosomal maintenance may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatments for conditions related to DNA damage and repair.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, making this approach both relevant and promising.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Kowalczykowski, Stephen Charles — University of California at Davis
- Study coordinator: Kowalczykowski, Stephen Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.