Understanding how DNA repair proteins help reprogram cells
Overcoming epigenetic barriers to somatic cell reprogramming by the XPC DNA repair complex
This study is looking at how a protein called XPC helps turn regular body cells into special cells that can become any type of cell, which is important for future treatments in medicine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10980661 on NIH RePORTER |
What this research studies
This research investigates the role of a specific DNA repair protein, XPC, in the process of reprogramming somatic cells into pluripotent cells, which can develop into any cell type. The study focuses on how XPC works with another enzyme, TDG, to remove chemical tags from DNA that prevent gene activation. By exploring these mechanisms, the research aims to uncover how cells can be directed to change their fate, which is crucial for advancements in regenerative medicine and developmental biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in regenerative therapies or those with conditions that could benefit from advancements in cell reprogramming.
Not a fit: Patients with conditions unrelated to cell reprogramming or those not interested in experimental therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved techniques for generating pluripotent cells, which have significant implications for regenerative medicine and treating various diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of DNA repair mechanisms in cell reprogramming, suggesting that this approach has potential for success.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Fong, Yick Wah — Brigham and Women's Hospital
- Study coordinator: Fong, Yick Wah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.