Understanding how DNA repair processes maintain accuracy during replication
Molecular control of translesion synthesis fidelity beyond the lesion
['FUNDING_R15'] · BAYLOR UNIVERSITY · NIH-10973368
This study is looking at how certain proteins help our cells copy DNA accurately, even when there’s damage, which is important for preventing mistakes that could lead to cancer.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR UNIVERSITY (nih funded) |
| Locations | 1 site (WACO, UNITED STATES) |
| Trial ID | NIH-10973368 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which DNA polymerases, specifically translesion synthesis (TLS) polymerases, bypass DNA damage while maintaining high fidelity during DNA replication. It aims to understand how these polymerases interact with other components of the replisome to ensure accurate DNA synthesis despite the presence of lesions. The study will explore the structural and kinetic factors that influence the fidelity of DNA replication and how these processes can prevent mutations that may lead to cancer. By examining these molecular interactions, the research seeks to uncover new insights into DNA repair mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of DNA repair deficiencies or those at high risk for cancers associated with DNA damage.
Not a fit: Patients with conditions unrelated to DNA damage or repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA repair processes, potentially informing new strategies for cancer prevention and treatment.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
WACO, UNITED STATES
- BAYLOR UNIVERSITY — WACO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRAKSELIS, MICHAEL A — BAYLOR UNIVERSITY
- Study coordinator: TRAKSELIS, MICHAEL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.