Understanding how DNA repair processes maintain accuracy during replication
Official title: Molecular control of translesion synthesis fidelity beyond the lesion
Funded at Baylor University · NIH-10973368 · Data updated 2026-11-12
This study is looking at how certain proteins help our cells copy DNA accurately, even when there’s damage, which is important for preventing mistakes that could lead to cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor University NIH-funded |
| Lab location | 1 site (Waco, United States) |
| Project start | July 2, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $420,000 |
| NIH project number | 1R15GM155805-01 |
| Project ID | NIH-10973368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of DNA repair deficiencies or those at high risk for cancers associated with DNA damage.
✕Less likely to help
Patients with conditions unrelated to DNA damage or repair mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms by which DNA polymerases, specifically translesion synthesis (TLS) polymerases, bypass DNA damage while maintaining high fidelity during DNA replication. It aims to understand how these polymerases interact with other components of the replisome to ensure accurate DNA synthesis despite the presence of lesions. The study will explore the structural and kinetic factors that influence the fidelity of DNA replication and how these processes can prevent mutations that may lead to cancer. By examining these molecular interactions, the research seeks to uncover new insights into DNA repair mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA repair processes, potentially informing new strategies for cancer prevention and treatment.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
-
Baylor University
Waco, United States Active
Researchers
- Principal investigator: Trakselis, Michael a — Baylor University
- Study coordinator: Trakselis, Michael a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.