Understanding how DNA repair processes contribute to breast cancer
Study of Break-induced Replication in Mammalian Cells
This study is looking at how a special way of fixing DNA called break-induced replication works in breast cancer cells, to see how it helps repair damage but can also cause problems that lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10756440 on NIH RePORTER |
What this research studies
This research investigates a specific DNA repair mechanism called break-induced replication (BIR) in mammalian cells, particularly its role in breast cancer. The study aims to understand how BIR can both repair DNA damage and potentially lead to genetic instability, which is a hallmark of cancer. Using a novel reporter system, researchers will analyze the genetic components involved in BIR and how it is influenced by factors like replication stress and oncogenic signals. By exploring the interactions of various proteins involved in this process, the research seeks to provide insights into the mechanisms that underlie genome stability and cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer or those at high risk for developing breast cancer due to genetic factors.
Not a fit: Patients with non-cancerous conditions or those not affected by genetic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating breast cancer by targeting DNA repair mechanisms.
How similar studies have performed: Previous studies have shown promising results in understanding DNA repair mechanisms in yeast, but this research aims to explore these processes in mammalian cells, making it a novel approach.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Wu, Xiaohua — Scripps Research Institute, the
- Study coordinator: Wu, Xiaohua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.