Understanding how DNA repair processes can lead to genome instability
Genome instability induced by homologous recombination
This study looks at how a natural DNA repair process can sometimes lead to problems in our genes, using yeast to help understand the patterns that might also happen in human cancers and genetic disorders, with the goal of learning more about how these changes happen over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10670239 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which homologous recombination, a process that repairs DNA, can inadvertently cause genome instability in cells. Using the budding yeast as a model, the study aims to identify specific mutational patterns that arise from DNA repair events involving repeated sequences. By analyzing these patterns, researchers hope to uncover insights that could relate to human cancer genomes and other genetic disorders. The findings may help clarify how certain genetic changes occur during development and evolution.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or genetic disorders related to genome instability.
Not a fit: Patients with stable genomes and no history of genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors contributing to cancer and other diseases, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown that understanding DNA repair mechanisms can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Heyer, Wolf-Dietrich — University of California at Davis
- Study coordinator: Heyer, Wolf-Dietrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.