Understanding how DNA repair processes can lead to genetic instability
Genome instability induced by homologous recombination
This study looks at how a natural DNA repair process can sometimes go wrong and cause problems in our genes, using yeast as a model to help us understand what happens when DNA repair doesn't work properly, which could also help us learn more about issues like cancer in humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10795314 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which homologous recombination, a process that repairs DNA, can inadvertently cause genome instability in cells. Using the budding yeast Saccharomyces cerevisiae as a model, the study aims to identify specific genetic changes that occur when DNA repair goes awry, particularly focusing on repeated DNA sequences. By uncovering these mutational signatures, the research seeks to shed light on similar processes in human cancer genomes and other conditions related to genomic instability. The findings could provide insights into how these mechanisms affect development and evolution.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with a family history of cancer or those diagnosed with genomic instability-related conditions.
Not a fit: Patients with stable genomes and no history of genetic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cancer development and potential new strategies for prevention or treatment.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms and their implications in cancer, making this approach both relevant and promising.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Heyer, Wolf-Dietrich — University of California at Davis
- Study coordinator: Heyer, Wolf-Dietrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.