Understanding how DNA repair mechanisms work in cancer cells
Official title: Unraveling DNA Polymerase Double-Strand Break Repair Strategies in Cancer
Funded at Univ of Arkansas for Med Scis · NIH-11049038 · Data updated 2026-11-12
This study is looking at how cancer cells fix their damaged DNA, which is important for stopping cancer from getting worse, and it aims to find out how certain proteins help with this repair, especially when it comes to making cancer treatments work better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | March 5, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $255,903 |
| NIH project number | 5P20GM152281-02 |
| Project ID | NIH-11049038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast, ovarian, or other types of cancers that may involve DNA repair issues.
✕Less likely to help
Patients with cancers that do not involve double-strand breaks or those who are not undergoing treatment that induces oxidative DNA damage may not benefit from this research.
What this research studies
This research investigates the ways in which cancer cells repair dangerous double-strand breaks in their DNA, which can lead to cancer progression if not handled properly. The team will explore the roles of specific DNA polymerases in these repair processes, particularly focusing on how they might contribute to resistance against certain cancer therapies. Using advanced imaging techniques and biochemical methods, the researchers aim to uncover the molecular details of these repair strategies. This knowledge could help in developing more effective cancer treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies that are more effective in overcoming resistance in patients.
How similar studies have gone: Other research has shown promise in understanding DNA repair mechanisms in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Jamsen, Joonas — Univ of Arkansas for Med Scis
- Study coordinator: Jamsen, Joonas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.