Understanding how DNA repair mechanisms work in cancer cells
Helicase regulation during homologous recombination
This study is looking at how our cells fix broken DNA, which is important because these breaks can lead to cancer, and it aims to find new ways to help treat cancer by focusing on the proteins that help with this repair process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10851688 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair damaged DNA, particularly focusing on double-stranded DNA breaks that can lead to cancer. By studying the proteins involved in homologous recombination, the research aims to uncover how these processes can be targeted for cancer therapies. The approach includes developing new experimental platforms to visualize DNA repair in action, which could lead to more effective treatments for patients with certain types of cancer. The findings may help identify specific inhibitors that can selectively target cancer cells while sparing healthy ones.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers associated with defects in DNA repair mechanisms.
Not a fit: Patients with cancers that do not involve homologous recombination deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for cancer that improve patient outcomes and reduce side effects.
How similar studies have performed: Previous research has shown promise in targeting DNA repair mechanisms in cancer therapy, indicating that this approach could be a significant advancement.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Greene, Eric C — Columbia University Health Sciences
- Study coordinator: Greene, Eric C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.