Understanding how DNA repair mechanisms work
Official title: Novel mechanisms in DNA mismatch repair
Funded at Southern Illinois University Carbondale · NIH-10686393 · Data updated 2026-11-12
This study is looking at how our cells fix mistakes in DNA, which is important for preventing cancer, by examining both yeast and human cells to find out more about how these repairs work and what happens when they go wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Illinois University Carbondale NIH-funded |
| Lab location | 1 site (Carbondale, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $295,000 |
| NIH project number | 5R01GM132128-04 |
| Project ID | NIH-10686393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of cancer or those who have experienced genetic mutations related to DNA repair.
✕Less likely to help
Patients with cancers unrelated to DNA mismatch repair mechanisms may not benefit from this research.
What this research studies
This research investigates the mismatch repair system, a crucial process that helps maintain the stability of our DNA by correcting errors that occur during DNA replication. By studying both yeast and human cells, the project aims to uncover novel mechanisms involved in this repair process, particularly focusing on how certain errors can lead to cancer. The research employs advanced techniques to analyze DNA mismatches and their repair, which could provide insights into the genetic factors contributing to cancer risk.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer development and potentially new strategies for prevention or treatment.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
Southern Illinois University Carbondale
Carbondale, United States Active
Researchers
- Principal investigator: Kadyrov, Farid — Southern Illinois University Carbondale
- Study coordinator: Kadyrov, Farid
Related research
Other NIH-funded projects on the same topics.
-
Rapid pathogen ID and antibiotic testing for bacteremia using immune capture, microfluidics, and AI
A fast, AI-assisted diagnostic system will identify bacteria in blood and determine which antibiotics are likely to work, helping doctors treat bacteremia sooner.
-
Electrografted-MoS2 Immunosensor for Biomarker Detection
A university-led project is developing a robust, covalently linked antibody–MoS2 biosensor to detect biomedical markers.
-
Super-Resolution Confocal Microscope for SIU researchers
A new high-resolution confocal microscope will be purchased for Southern Illinois University, enabling researchers from multiple fields to generate clearer 3D images and advance biomedical work.
-
How social choices shape when to stay with a friend vs. seek food in mice
A study in mice will look at how the brain decides whether to stay with a social partner or pursue food when both options are available.
-
High-speed cell sorting technology for cancer and infectious disease research
A fast, multi-marker cell sorter is being purchased to help SIUC researchers study cancer, immune responses, and infections, plus train students in this cutting-edge technique.
-
How early life stress affects aggression through brain circuitry
This study is looking at how tough experiences in childhood, like feeling alone or going through trauma, can affect the brain and lead to aggressive behavior in adults, with the hope of finding better ways to help people manage their anger.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.