Understanding how DNA repair mechanisms maintain genetic health and influence gene regulation
Mechanisms of BER in Genomic Integrity and Epigenetic Regulation
This study is looking at how our bodies fix damaged DNA and how problems with this process might lead to diseases like cancer, so patients can learn more about how their genes affect their health and treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10887924 on NIH RePORTER |
What this research studies
This research investigates the base excision repair (BER) pathway, which is crucial for maintaining the integrity of our DNA and regulating gene expression. The focus is on how specific enzymes, known as DNA glycosylases, identify and remove damaged DNA bases, particularly those modified by methylation. By studying these processes, the research aims to uncover how deficiencies in DNA repair can lead to diseases such as cancer. Patients may benefit from insights into how their genetic makeup influences disease risk and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with a family history of cancer or genetic disorders related to DNA repair deficiencies.
Not a fit: Patients with no known genetic predispositions or those not affected by conditions related to DNA repair may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic diseases and the development of targeted therapies.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Drohat, Alex C — University of Maryland Baltimore
- Study coordinator: Drohat, Alex C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.