Understanding how DNA repair helps cells cope with stress
Role of homologous recombination in the replication stress response
['FUNDING_OTHER'] · CLEMSON UNIVERSITY · NIH-11086852
This study is looking at how a special DNA repair process helps keep our genes safe when things get tough, and it could lead to new treatments for people with genetic disorders or a higher risk of cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEMSON UNIVERSITY (nih funded) |
| Locations | 1 site (CLEMSON, UNITED STATES) |
| Trial ID | NIH-11086852 on ClinicalTrials.gov |
What this research studies
This research investigates the role of homologous recombination, a critical DNA repair process, in maintaining genome stability during stressful conditions. By examining how this process functions at stalled DNA replication forks, the study aims to uncover the mechanisms that protect our genetic material from damage. The research employs advanced genetic and molecular biology techniques to explore the behavior of specific proteins involved in DNA repair. This knowledge could lead to new therapeutic strategies for patients with genetic disorders related to chromosomal instability and cancer predisposition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inherited chromosomal instability disorders or those with a family history of cancer predisposition.
Not a fit: Patients without genetic predispositions to chromosomal instability or cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for patients with genetic conditions that increase their risk of cancer.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
CLEMSON, UNITED STATES
- CLEMSON UNIVERSITY — CLEMSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASON, JENNIFER — CLEMSON UNIVERSITY
- Study coordinator: MASON, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer predisposition, Cancers, Disease, Disorder