Understanding how DNA repair enzymes work
Official title: Mechanisms of Base Excision DNA Repair
Funded at University of Michigan at Ann Arbor · NIH-11098931 · Data updated 2026-11-12
This study is looking at how certain enzymes help fix DNA damage caused by things like aging and the environment, which could help us understand genetic mutations and improve treatments for diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $217,765 |
| NIH project number | 3R35GM149546-02S1 |
| Project ID | NIH-11098931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of genetic mutations or those at risk for diseases related to DNA damage.
✕Less likely to help
Patients with conditions unrelated to DNA damage or repair mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms by which DNA repair enzymes function to fix damage caused by various factors, including aging and environmental exposures. By studying these enzymes, the research aims to uncover the biochemical and biophysical principles that are crucial for effective DNA repair. The findings could lead to better understanding of how genetic mutations occur and how they relate to diseases like cancer. The research employs an interdisciplinary approach, integrating structural and biophysical data to provide insights that could improve treatment strategies for conditions involving DNA damage.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancer and other diseases caused by DNA damage.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach has the potential for significant advancements.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: O'brien, Patrick J — University of Michigan at Ann Arbor
- Study coordinator: O'brien, Patrick J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.