Understanding how DNA repair enzymes work
Mechanisms of Base Excision DNA Repair
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11059179
This study is looking at how certain enzymes help fix damage to our DNA, which can happen from things inside our bodies or from outside sources, and it's especially important for improving cancer treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11059179 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which DNA repair enzymes function to fix damage in our DNA, which can occur from both internal and external sources. By studying these enzymes, the research aims to uncover the biochemical and biophysical principles that are crucial for effective DNA repair. This understanding is particularly important for improving treatments for diseases like cancer, where DNA damage is a significant concern. The research employs an interdisciplinary approach, integrating various structural and biophysical data to gain insights into DNA repair processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing cancer treatment or those at risk of developing cancer due to DNA damage.
Not a fit: Patients with conditions unrelated to DNA damage or repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach has potential for significant advancements.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: O'BRIEN, PATRICK J — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: O'BRIEN, PATRICK J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Cancer Causing Agents, cancer therapy