Understanding how DNA repair affects tissue health in mice lacking a specific repair gene
Genotoxic stress response and mutagenesis in normal tissues of mice deficient in homology directed repair
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11010787
This study is looking at how the missing Brca1 gene affects the health of tissues in mice when they face environmental challenges that can harm their DNA, helping us understand how different repair systems work to keep our cells safe from damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11010787 on ClinicalTrials.gov |
What this research studies
This research investigates how the absence of a key DNA repair gene, Brca1, affects the health and integrity of tissues in mice when exposed to environmental stresses that damage DNA. By using genetically engineered mice that can lose this gene after development, the study aims to uncover the role of different DNA repair pathways in maintaining tissue viability and preventing mutations. The research will explore how various tissues respond to DNA damage and the interplay between different repair mechanisms, providing insights into the biological processes that protect against genetic damage.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with a genetic predisposition to conditions related to DNA repair deficiencies, such as those with BRCA1 mutations.
Not a fit: Patients without genetic predispositions to DNA repair deficiencies or those not affected by related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding of DNA repair mechanisms, potentially informing treatments for conditions related to DNA damage, such as cancer.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms in various models, but this specific approach using inducible gene deletion in adult mammals is relatively novel.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACKSON, JAMES — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: JACKSON, JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.