Understanding how DNA repair affects fertility and birth defects
Chromatin-mediated maintenance of genomic integrity in germ cells
This study looks at how DNA damage can affect reproductive cells, which are important for having healthy babies, and it uses tiny worms to learn more about how these cells fix their DNA to help prevent infertility and miscarriages.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marist College NIH-funded |
| Lab location | 1 site (Poughkeepsie, United States) |
| Project ID | NIH-10291840 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which DNA damage affects germ cells, which are essential for reproduction. It focuses on how DNA repair pathways function in these cells and their importance in preventing infertility and miscarriages. By using a model organism, Caenorhabditis elegans, the study aims to uncover the molecular processes that guide DNA repair and how they can impact genetic integrity. The findings could provide insights into the causes of developmental disorders linked to DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility, recurrent miscarriages, or those with a family history of congenital abnormalities.
Not a fit: Patients who are not experiencing reproductive issues or congenital abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and congenital birth defects.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms in other contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
Poughkeepsie, United States
- Marist College — Poughkeepsie, United States (Active)
Researchers
- Principal investigator: Woolridge, Elisa — Marist College
- Study coordinator: Woolridge, Elisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.