Understanding how DNA polymerase beta selects the right building blocks for DNA repair
Official title: Fidelity Mechanisms of DNA Polymerase Beta
Funded at University of Nebraska Medical Center · NIH-11051772 · Data updated 2026-11-12
This study looks at how a special enzyme helps fix DNA and make sure the right building blocks are used, which is important for preventing mistakes that can lead to diseases like cancer, and the findings could help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | March 7, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $620,415 |
| NIH project number | 5R01CA281044-02 |
| Project ID | NIH-11051772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a genetic predisposition to cancer or those undergoing treatment that affects DNA repair mechanisms.
✕Less likely to help
Patients with conditions unrelated to DNA repair or those not affected by mutations in their genome may not benefit from this research.
What this research studies
This research investigates the mechanisms by which DNA polymerase beta (Pol β) selects the correct nucleotides during DNA replication and repair. By focusing on the process of base excision repair, the study aims to uncover how errors in nucleotide incorporation can lead to mutations, which are linked to diseases like cancer. The research employs biochemical and biophysical methods to analyze Pol β's substrate selection, which is crucial for maintaining genomic stability and immune diversity. Patients may benefit from insights gained into how DNA repair processes can be improved or targeted in cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for diseases caused by DNA mutations, including various cancers.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach is built on established scientific principles.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Sweasy, Joann B. — University of Nebraska Medical Center
- Study coordinator: Sweasy, Joann B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.